A Special Font for People with Dyslexia: Does it Work and, if so, why?

High Fluoride Dentifrices for Elderly and Vulnerable Adults: Does It Work and if So, Then Why?

The primary aim of this work is to present the available evidence that toothpastes containing >1,500 ppm fluoride (2,500-2,800 and 5,000 ppm F) provide an additional caries preventive effect on root caries lesions in elderly patients compared to traditional dentifrices (1,000-1,450 ppm F). The secondary aim of this paper is to discuss why high fluoride dentifrices in general should perform bett...

Allergen immunotherapy: does it work and, if so, how and for how long?

Background. Pollen immunotherapy is effective in selected patients with IgE-mediated seasonal allergic rhinitis, although it is questionable whether there is long-term benefit after the discontinuation of treatment. Methods. We conducted a randomised, double-blind, placebo-controlled trial of the discontinuation of immunotherapy for grass pollen allergy in patients in whom three to four years o...

Stem cell transplantation for stroke: does it work, and if so, how?

Why Do People Work so Hard?

Conventional economic theory, coupled with standard preference parameters predict that labor supply should fall markedly over time. However, this contradicts the empirical reality that labor supply rises at the very onset of economic development, subsequently tends to fall, and then stabilizes. This paper addresses this pattern of labor supply over time, and explains it via the proliferation of...

Why Does BitTorrent Work So Well?

BitTorrent (BT) is currently the most popular file-sharing peer-to-peer (P2P) clients [1]. Several reports have shown that it accounts for the majority of peer-to-peer traffic, up to one third of the global Internet traffic. However, leaving the media attention aside for one moment, we ask the question: Why does BT work so well? BT attempts to build robustness to freeloading (i.e. downloading w...